Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar testing. Some MEDICINES MAY INTERACT with acarbose. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make.
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products.
Acarbose corresponding to 10 times the dose in man, based on body surface area showed no evidence of embryotoxicity and there was no evidence of teratogenicity at a dose 32 times the dose in man based on body surface area. There are, however, no adequate and well-controlled studies of Acarbose Tablets in pregnant women. Because animal reproduction studies are not always predictive of the human response, this drug should be used during pregnancy only if clearly needed. Because current information strongly suggests that abnormal blood glucose levels during pregnancy are associated with a higher incidence of congenital anomalies as well as increased neonatal morbidity and mortality, most experts recommend that insulin be used during pregnancy to maintain blood glucose levels as close to normal as possible.
Drink liquids 30 to 45 minutes after meals. People with diabetes must take acarbose with the first bite of food at each meal. Acarbose may be used alone as the only diabetes medicine, or with the group of blood-sugar-lowering medicines called sulfonylureas, such as the brand names Diabeta, Glucotrol, and Micronase. The dose of acarbose will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of acarbose. Do not share this medication with others. Use acarbose as directed by your doctor. Check the label on the medicine for exact dosing instructions.
The information contained in the Truven Health Micromedex products as delivered by Drugs. Choose from Top Nursing Uniform Companies. All sizes, styles and popular name brands available. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Acarbose. In rabbits, reduced maternal body weight gain, probably the result of the pharmacodynamic activity of high doses of Acarbose in the intestines, may have been responsible for a slight increase in the number of embryonic losses. Before taking acarbose, tell your doctor if you have liver disease, or any type of stomach or intestinal disorder. Inform your doctor if your condition persists or worsens. Renal Impairment: Plasma concentrations of Acarbose Tablets in renally impaired volunteers were proportionally increased relative to the degree of renal dysfunction. It is recommended that serum transaminase levels be checked every 3 months during the first year of treatment with Acarbose Tablets and periodically thereafter. If elevated transaminases are observed, a reduction in dosage or withdrawal of therapy may be indicated, particularly if the elevations persist. In contrast to sulfonylureas, Acarbose Tablets do not enhance insulin secretion. The antihyperglycemic action of Acarbose results from a competitive, reversible inhibition of pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolase enzymes. Pancreatic alpha-amylase hydrolyzes complex starches to oligosaccharides in the lumen of the small intestine, while the membrane-bound intestinal alpha-glucosidases hydrolyze oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the brush border of the small intestine. In diabetic patients, this enzyme inhibition results in a delayed glucose absorption and a lowering of postprandial hyperglycemia. Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team. It is a group of symptoms that may result from having part of your removed or from other surgery involving the stomach. The symptoms range from mild to severe and often subside with time. Although you may find dumping syndrome alarming at first, it is not life threatening. You can control it by making changes in what and how you eat. Other symptoms of low blood sugar such as dizziness, hunger, and sweating are unaffected by these drugs. Do not use this medication if you are allergic to acarbose, or if you are in a state of diabetic ketoacidosis call your doctor for treatment with insulin. You also should not use acarbose if you have inflammatory bowel disease, an ulcer or blockage in your intestines, or cirrhosis of the liver. Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide diltiazem Cartia, Cardizem nifedipine Nifedical, Procardia verapamil Calan, Covera, Isoptin, Verelan and others.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. If you miss a dose of Glycomet, take as soon as possible. Do not double doses. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. It is not known whether acarbose passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using acarbose. Take the missed dose as soon as you remember be sure to take it with a meal. If it has been longer than 15 minutes since you started your meal, you may still take acarbose but it may be less effective than taking it with the first bite of the meal. Do not take acarbose between meals, and do not take extra medicine to make up a missed dose. What happens if I overdose? decadron
The bottom line is today's longetivity is only attributed to advances in medicine that prevent death from early disease or otherwise thwart the natural selection Darwinism process. Especially since I cannot stand seafood. If any of these effects persist or worsen, tell your doctor or promptly. Keep all medicines away from children and pets. Acarbose Tablets should be adjusted at 4-8 week intervals based on one-hour postprandial glucose or glycosylated hemoglobin levels, and on tolerance. Using acarbose with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Combine proteins or fats along with fruits or starches. For example, combine fruit with cottage cheese. If you take acarbose with insulin or other diabetes medications, your blood sugar could get too low. Low blood sugar hypoglycemia can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, or trouble concentrating. For acarbose to work properly it must be taken at the beginning of each main meal. Food and Drug Administration FDA approved the use of acarbose for managing Type 2 diabetes. The brand name for acarbose is Precose. Acarbose blocks the enzymes that digest starches from food. This causes a slower and lower rise of blood sugar through the day. Acarbose is especially effective right after meals. Sulfonylurea agents or insulin may cause hypoglycemia. Some medical conditions may interact with acarbose. Use and dose must be determined by your doctor. Acarbose Tablets are available as 25 mg, 50 mg or 100 mg, circular biconvex tablets. Each tablet strength is white to off white in color. The 25 mg tablet is engraved with 'P210' on one side and '25' on the other side. The 50 mg tablet is engraved with 'P211' on one side and '50' on the other side. The 100 mg tablet is engraved with 'P212' on one side and '100' on the other side. Acarbose Tablets are available in bottles of 100. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. In initiating treatment for type 2 diabetes mellitus, diet should be emphasized as the primary form of treatment. Caloric restriction and weight loss are essential in the obese diabetic patient. Proper dietary management alone may be effective in controlling blood glucose and symptoms of hyperglycemia. The importance of regular physical activity when appropriate should also be stressed. awab.info tenormin
What happens if I overdose Precose? Acarbose is metabolized exclusively within the gastrointestinal tract, principally by intestinal bacteria, but also by digestive enzymes. A fraction of these metabolites approximately 34% of the dose was absorbed and subsequently excreted in the urine. At least 13 metabolites have been separated chromatographically from urine specimens. The major metabolites have been identified as 4-methylpyrogallol derivatives that is, sulfate, methyl, and glucuronide conjugates. One metabolite formed by cleavage of a glucose molecule from Acarbose also has alpha-glucosidase inhibitory activity. This metabolite, together with the parent compound, recovered from the urine, accounts for less than 2% of the total administered dose. TA and S--TA as well as glibenclamide concentrations were measured with specific analytical methods. RESULTS: There was no clinically relevant change of TA enantiomer pharmacokinetics by glibenclamide or acarbose. Also, glibenclamide pharmacokinetics were not altered by TA to a clinically meaningful extent. Plasma insulin and glucose concentrations did not indicate an interaction between TA and glibenclamide or TA and acarbose. Glibenclamide had the expected effect on insulin and glucose levels independent of comedication. There were only minor and short lasting adverse events with the majority being expected hypoglycaemic symptoms occurring during the treatments with glibenclamide. Take acarbose by mouth at the start with the first bite of each main meal. You may be more likely to have hyperglycemia high blood sugar if you are taking acarbose with other drugs that raise blood sugar. As a species, we have been eating "modern" food for only about the past 75 years. Follow carefully the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed. Glycomet may cause side effects.
Ask your health care provider any questions you may have about how to use acarbose. Carefully follow the regular testing of urine or blood glucose schedules given to you by your health care provider. If you miss a dose of acarbose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Also watch for signs of high blood sugar hyperglycemia such as increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss. Keep out of the reach of children. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. What is acarbose Precose? You should take the prescribed dose with the FIRST BITE of each main meal. A small dose will be started and your health care provider will gradually increase it as needed. Your health care provider may want you to combine Precose with another type of diabetes pill. Since Precose works differently than the other diabetes pills, it will not interfere with their action. Combined with these pills, Precose may further improve your control. If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. drugstore prices for fenofibrate
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Do not use table sugar also called cane sugar or sucrose to relieve these symptoms because acarbose delays its breakdown. Carry glucose tablets or gel with you to treat low blood sugar. If you are in a situation where you don't have these reliable forms of glucose, eat some honey or drink a glass of orange juice sources of another sugar, fructose to quickly raise your blood sugar level. Tell your doctor about the reaction right away. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal. At first the dose is 25 milligrams mg three times a day, at the start of each main meal. Your dose may then be adjusted by your doctor. Acarbose slows the digestion of carbohydrates in the body, which helps control blood sugar levels. A1c, complete blood counts should be performed periodically to check for side effects and monitor your response to therapy. Check your blood or urine sugar levels regularly as directed by your doctor or pharmacist. There may be a time when you need emergency help for a problem caused by your diabetes. You need to be prepared for these emergencies. It is a good idea to wear a medical identification ID bracelet or neck chain at all times. Also, carry an ID card in your wallet or purse that says that you have diabetes and a list of all of your medicines. In a study of 6 healthy men, less than 2% of an oral dose of Acarbose was absorbed as active drug, while approximately 35% of total radioactivity from a 14C-labeled oral dose was absorbed. An average of 51% of an oral dose was excreted in the feces as unabsorbed drug-related radioactivity within 96 hours of ingestion. Because Acarbose acts locally within the gastrointestinal tract, this low systemic bioavailability of parent compound is therapeutically desired. Following oral dosing of healthy volunteers with 14C-labeled Acarbose, peak plasma concentrations of radioactivity were attained 14-24 hours after dosing, while peak plasma concentrations of active drug were attained at approximately 1 hour. The delayed absorption of Acarbose-related radioactivity reflects the absorption of metabolites that may be formed by either intestinal bacteria or intestinal enzymatic hydrolysis. buy sucralfate junior
Precose therapy or placebo, titrating to a maximum dose of 100 mg three times daily. Take acarbose with the first bite of a main meal, unless your doctor tells you otherwise. This list is not complete. Other drugs may interact with acarbose, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; bloody stools; severe or persistent diarrhea or constipation; severe stomach pain; unusual bleeding or bruising. HbA1c levels from baseline throughout a one-year study in patients with type 2 diabetes mellitus when used in combination with: A diet alone; B sulfonylurea; C metformin; or D insulin. If side effects occur with Acarbose Tablets, they usually develop during the first few weeks of therapy. They are most commonly mild-to-moderate gastrointestinal effects, such as flatulence, diarrhea, or abdominal discomfort, and generally diminish in frequency and intensity with time. Do NOT take more than the recommended dose without checking with your doctor. Acarbose Tablets as monotherapy or in combination with sulfonylurea, metformin or insulin treatment was conducted in Canada in which 316 patients were included in the primary efficacy analysis Figure 2. In the diet, sulfonylurea and metformin groups, the mean decrease in HbA1c produced by the addition of Acarbose Tablets was statistically significant at six months, and this effect was persistent at one year. In the Acarbose Tablets-treated patients on insulin, there was a statistically significant reduction in HbA1c at six months, and a trend for a reduction at one year.
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Fertility studies conducted in rats after oral administration produced no untoward effect on fertility or on the overall capability to reproduce. It is not known whether this drug passes into milk. Consult your doctor before -feeding. Symptoms of an early phase happen because food is rapidly "dumping" into the small intestine. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately: chest pain, rash. Teratogenic Effects: Pregnancy Category B. The safety of Acarbose Tablets in pregnant women has not been established. gefitinib
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Patients Receiving Sulfonylureas or Insulin: Sulfonylurea agents or insulin may cause hypoglycemia. Acarbose Tablets given in combination with a sulfonylurea or insulin will cause a further lowering of blood glucose and may increase the potential for hypoglycemia. If hypoglycemia occurs, appropriate adjustments in the dosage of these agents should be made. Digestive Tract: Gastrointestinal symptoms are the most common reactions to Acarbose Tablets.
If you have any questions about acarbose, please talk with your doctor, pharmacist, or other health care provider. Its action is quite different from sulfonylureas and metformin. By slowing the digestion of carbohydrates in the small intestine, the blood sugar rise after a meal is lessened. Acarbose works by inhibiting enzymes in the intestine that break carbohydrates down, so glucose levels rise more slowly and the person's own internal production of insulin can more easily respond. Clinical Experience in Type 2 Diabetes Mellitus Patients on Monotherapy, or in Combination with Sulfonylureas, Metformin or Insulin: Acarbose Tablets were studied as monotherapy and as combination therapy to sulfonylurea, metformin, or insulin treatment. The treatment effects on HbA1c levels and one-hour postprandial glucose levels are summarized for four placebo-controlled, double-blind, randomized studies conducted in the United States in Tables 2 and 3, respectively. The placebo-subtracted treatment differences, which are summarized below, were statistically significant for both variables in all of these studies. motilium
Acarbose Tablets were statistically significantly different from placebo at all doses with respect to effect on one-hour postprandial plasma glucose. Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Proper diet, regular exercise, and regular blood sugar testing are important for best results with acarbose. Follow the diet and exercise program given to you by your health care provider. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Go for complex carbohydrates, such as vegetables and whole-wheat bread, instead of simple carbohydrates, such as sweet rolls and ice cream.